IndraLab

Statements


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"We conclude that local administration of NO may prevent the formation of neointimal hyperplasia by inhibiting isopeptidase T activity via S nitrosylation, resulting in accumulation of unanchored polyubiquitin chains and further inhibiting the 26S proteasome."

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"NO causes S nitrosylation of isopeptidase T in a time dependent manner."

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"Local administration of NO may prevent neointimal hyperplasia by targeting isopeptidase T and inhibiting the 26S proteasome."