IndraLab

Statements

Heme inhibits KCNMA1. 2 / 2
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"Application of heme (100 nM) to the cytoplasmic side of the channel progressively decreased the Slo1 current size at 160 mV to ~ 36 +/- 19% (n = 17) of the control amplitude with a pseudo second-order rate constant of 2.2 x 10 5 +/- 1.2 x 10 4 s -1 * M -1 (n = 17; XREF_FIG A)."
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"Specifically, CO reverses heme-induced BK channel inhibition by impairing the interaction between heme and its conserved binding domain (Jaggar et al., 2005)."
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