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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Heme inhibits KCNMA1. 2 / 2

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"Specifically, CO reverses heme-induced BK channel inhibition by impairing the interaction between heme and its conserved binding domain (Jaggar et al., 2005)."

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"Application of heme (100 nM) to the cytoplasmic side of the channel progressively decreased the Slo1 current size at 160 mV to ~ 36 +/- 19% (n = 17) of the control amplitude with a pseudo second-order rate constant of 2.2 x 10 5 +/- 1.2 x 10 4 s -1 * M -1 (n = 17; XREF_FIG A)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...