IndraLab

Statements

USP13 activates Neoplasm Metastasis. 23 / 23
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"USP13 promotes breast cancer cell migration, invasion and lung metastasis through Twist1."
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"These data underscore a key role of Twist1 in USP13-induced enhancement of lung metastasis in breast cancer."
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"Taken together, these data indicated that USP13 accelerated OS metastasis in vitro and in vivo."
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"Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein."
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"Importantly, overexpression of Usp13 accelerates tumorigenesis, enhances tumor metastasis, and causes poor outcomes in transgenic mouse models of ovarian cancer , underscoring its importance in promoting tumorigenesis in vivo."
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"In hepatocellular carcinoma, the tumor growth and metastasis are promoted by USP13 through its regulation of TLR4 and subsequent activation of the TLR4/MyD88/NF-κB signaling cascade [23]."
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"Snail can be maintained by USP13 to trigger EMT and metastasis, resulting in the poor prognosis of GC patients indirectly [58]."
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"USP13 signaling in tumor metastasis."
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"USP13 promotes OS cells metastasis."
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"30 , 31 Similarly, silence of USP13 greatly abrogated the lung and liver metastases from subcutaneous tumors ( Figures S2 A–S2C)."
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"USP13 promoted HCC cell growth and metastasis by regulating the TLR4/MyD88/NF-κB pathway [37]."
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"Notably, USP13 greatly enhanced peritoneal metastasis of ovarian tumors with frequent development of hemorrhagic ascites."
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"USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model."
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"In present study, we found that USP13 promotes glycolysis and progression in OS.To further explore the underlying mechanisms and protein-protein interactions by which USP13 promotes proliferation and metastasis of OS cells, IP/MS was performed and METTL3 was identified as a putative protein that binds to USP13."
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"We also detected the bioluminescence intensity in lung to examine whether USP13 could affect the lung metastasis of ccRCC in vivo and found that depletion of USP13 inhibited lung metastasis (Fig. 4 K and L)."
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"27 , 29 In the present study, we showed that USP13 enhances NSCLC metastasis, and its high expression is tightly associated with poor survival of NSCLC patients."
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"In vivo, the expression of WT-USP13, particularly USP13-Y708E construct in HCCC9810 cells, significantly enhanced the metastasis and growth of CCA cells, while the USP13-Y708F construct was resistant to carcinogenesis after implanting in nude mice (XREF_FIG)."
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"Ubiquitin-specific Peptidase 13 (USP13) is highly amplified and promotes tumorigenesis and metastasis in ovarian cancer."
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"USP13 is highly amplified in human ovarian cancer, and elevated expression of USP13 promotes tumorigenesis and metastasis of ovarian cancer."
36612196
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"The objective was to determine whether USP13 stabilizes WISP1 protein and contributes to tumorigenicity and metastasis in ESCC through the Wnt/CTNNB1 signaling pathway."
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"In our genetically engineered mouse model, USP13 overexpression promoted ovarian tumorigenesis and metastasis [14]."
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"In vivo, USP13 knockdown significantly inhibited tumor growth and lung metastasis."
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"We found that USP13 promotes breast cancer metastases through Twist1 de-ubiquitination."
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