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OTUB2 activates PRRT2. 4 / 4
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"These indicate that OTUB2 promotes the metastasis of iCCA cells through ZEB1-regulated EMT.CTNNB1 signaling is involved in many physiological and pathological processes, as shown in previous works [ 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results indicate that OTUB2-regulated expression of ZEB1 enhances EMT to promote invasion and metastasis in iCCA cells ( Fig. 4 E and F)."
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"Therefore, we next sought to ascertain the underlying molecular mechanism of OTUB2-mediated iCCA pathogenesis.Previous studies established that ZEB1 promotes the metastasis of AML and kidney and pancr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The present work demonstrated that OTUB2 knockdown significantly inhibited the proliferation of iCCA cells while promoting apoptosis, suggesting that increased cell proliferation and decreased apoptos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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