IndraLab

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Caspase phosphorylates EIF3F. 2 / 2
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"The phosphorylation of the eIF3f subunit by the caspase activated form of CDK11 (cyclin dependent kinase 11) is also noteworthy [XREF_BIBR]."
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"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [XREF_BIBR] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation."
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