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USP22 increases the amount of VEGFA. 9 / 9
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"The results demonstrated that the transcription of VEGFA was downregulated by USP22 deletion, in contrast, ectopic expression of USP22 increased VEGFA transcription (Fig. 2D–F)."
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"Dual luciferase assay results showed that USP22 significantly upregulated VEGFA transcription (Fig. 2G)."
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"Western blotting experiments showed that the upregulation of VEGFA by USP22 was inhibited in the absence of ZEB1 (Fig. 2I), this suggested that the up-regulation of VEGFA transcription by USP22 was partly dependent on ZEB1 expression."
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"Western blotting experiments showed that the upregulation of VEGFA by USP22 was inhibited in the absence of ZEB1 (Fig. xref ), this suggested that the up-regulation of VEGFA transcription by USP22 was partly dependent on ZEB1 expression."
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"The results demonstrated USP22 knockdown reduced mRNA or protein expression of VEGFA."
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"The results showed that, overexpression of USP22 significantly promoted the growth of HCC, and knockdown of ZEB1 inhibited the effect of USP22 on tumor growth (Fig. 6G–J), suggesting that ZEB1 was involved in the development of HCC, and the promotion of HCC growth by USP22 was partially related to ZEB1.In addition, the results from immunohistochemistry showed that USP22 depletion decreased USP22, ZEB1, or VEGFA expression in xenograft tumors."
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"The results showed that USP22 deletion inhibited VEGFA secretion (Fig. 5H)."
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"USP22 increases ZEB1-induced VEGFA transcription in HCC cells."
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"Western blotting results showed that the protein expression of VEGFA was decreased by knockdown of USP22, while the protein expression of VEGFA was upregulated by overexpression of USP22 (Fig. 2A–C)."
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