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Metformin inhibits CASP1. 12 / 12
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"Immunohistochemical staining, immunofluorescence staining and western blot assays indicated that the expression levels of mTOR, NLRP3, caspase-1, IL-1beta and GSDMD-N were decreased in the diabetic model treated with metformin and were reversed after the administration of an AMPK inhibitor in vivo and in vitro."
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"In addition, inflammation cell death factors, p-MLKL and caspase 1, are decreased by metformin treatment in OA chondrocytes.A recent study showed the chondroprotective effect of metformin in injury-induced OA animal models [23], which is consistent with our result."
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"As predicted, metformin-treated Mtb-infected mice had reduced numbers of CD8 caspase-1 cells in the spleen compared to the untreated Mtb-infected mice (Fig. 4d)."
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"However, metformin still inhibited Casp1 activation and IL-1beta secretion in p62- and ATG7 deficient macrophages (XREF_SUPPLEMENTARY A-S3D), indicating that metformin 's effect is mitophagy independent."
| PMC
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"Lee et al. [XREF_BIBR] showed that levels of IL-1beta maturation and caspase-1 cleavage are decreased in monocyte derived macrophages from T2DM patients treated with metformin, an anti-diabetic drug."
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"We further found that metformin significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central hippocampus."
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"Importantly , metformin inhibited Casp1 activation and pro-IL-1beta processing to mature IL-1beta in LPS-primed macrophages incubated with either ATP , nigericin ( Nig ) , alum , or monosodium urate ( MSU ) crystals , although the effect on nigericin-challenged macrophages was relatively modest ( Figures 2B and S2B-S2D ) ."
| PMC
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"Lee, H. M et al. found that metformin could inhibit IL-1beta and caspase-1 through activation of the AMPK pathway [30]."
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"In our study, we observed that Metformin significantly suppressed accumulation of the NLRP3 inflammasome and activation of Caspase-1."
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"However , metformin still inhibited Casp1 activation and IL-1beta secretion in p62 - and ATG7-deficient macrophages ( Figures S3A-S3D ) , indicating that metformin 's effect is mitophagy independent ."
| PMC
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"Importantly, metformin inhibited Casp1 activation and pro-IL-1beta processing to mature IL-1beta in LPS primed macrophages incubated with either ATP, nigericin (Nig), alum, or monosodium urate (MSU) crystals, although the effect on nigericin challenged macrophages was relatively modest (XREF_FIG B and XREF_SUPPLEMENTARY B-S2D)."
| PMC
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"Also , metformin blocks caspase-1 and GSDMD-N that correlate with the NLRP3 inflammasome activation ."
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