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Metformin inhibits CASP1. 17 / 17
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"Interestingly, treatment with metformin for two months has been shown to reverse the increase in caspase-1 activation and myeloid cell production of IL-1β and IL-18 in drug-naïve T2DM patients by activating AMP-activated protein kinase [66]."
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"As predicted, metformin-treated Mtb-infected mice had reduced numbers of CD8 caspase-1 cells in the spleen compared to the untreated Mtb-infected mice (Fig. 4d)."
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"We further found that metformin significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central hippocampus."
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"Lee, H. M et al. found that metformin could inhibit IL-1beta and caspase-1 through activation of the AMPK pathway [30]."
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"In human bronchial and lung epithelial cell lines infected with SARS-CoV-2, metformin restored autophagic flux, inhibited cleavage of caspase-1 by non-structural protein 6 (NSP6), and inhibited matura[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, metformin inhibited Casp1 activation and pro-IL-1beta processing to mature IL-1beta in LPS primed macrophages incubated with either ATP, nigericin (Nig), alum, or monosodium urate (MSU) crystals, although the effect on nigericin challenged macrophages was relatively modest (XREF_FIG B and XREF_SUPPLEMENTARY B-S2D)."
| PMC
eidos
"Importantly , metformin inhibited Casp1 activation and pro-IL-1beta processing to mature IL-1beta in LPS-primed macrophages incubated with either ATP , nigericin ( Nig ) , alum , or monosodium urate ( MSU ) crystals , although the effect on nigericin-challenged macrophages was relatively modest ( Figures 2B and S2B-S2D ) ."
| PMC
eidos
"Also , metformin blocks caspase-1 and GSDMD-N that correlate with the NLRP3 inflammasome activation ."
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"In addition, inflammation cell death factors, p-MLKL and caspase 1, are decreased by metformin treatment in OA chondrocytes.A recent study showed the chondroprotective effect of metformin in injury-induced OA animal models [23], which is consistent with our result."
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"In our study, we observed that Metformin significantly suppressed accumulation of the NLRP3 inflammasome and activation of Caspase-1."
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"Lee et al. [XREF_BIBR] showed that levels of IL-1beta maturation and caspase-1 cleavage are decreased in monocyte derived macrophages from T2DM patients treated with metformin, an anti-diabetic drug."
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"Lee et al. (139) found that metformin could inhibit Caspase-1 and IL-1β by activating the AMPK pathway, thus improving insulin sensitivity."
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"In human bronchial and lung epithelial cell lines infected with SARS-CoV-2, metformin restored autophagic flux, inhibited cleavage of caspase-1 by non-structural protein 6 (NSP6), and inhibited maturation and release of interleukin-1β and interleukin-18."
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"However, metformin still inhibited Casp1 activation and IL-1beta secretion in p62- and ATG7 deficient macrophages (XREF_SUPPLEMENTARY A-S3D), indicating that metformin 's effect is mitophagy independent."
| PMC
eidos
"However , metformin still inhibited Casp1 activation and IL-1beta secretion in p62 - and ATG7-deficient macrophages ( Figures S3A-S3D ) , indicating that metformin 's effect is mitophagy independent ."
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"Importantly, metformin inhibited Casp1 activation and pro-IL-1β processing to mature IL-1β in LPS-primed macrophages incubated with either ATP, nigericin (Nig), alum, or monosodium urate (MSU) crystal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, metformin significantly reversed MDA (p = 0.007), SOD (p = 0.007), catalase (p = 0.006), TNF (p = 0.04), presenilin 1 (p = 0.005), p-Tau (p = 0.02), caspase 1 (p = 0.03), and caspase 3 (p = 0.01) besides significant elevation of IL-10 (Fig. 4B, two-way ANOVA, p < 0.001, interaction TMT x metformin: F  = 13.87, p = 0.001)."
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