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USP22 activates PPAR. 6 / 6
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"USP22 promotes lipogenesis in Tregs through stabilization of peroxisome proliferator-activated receptor gamma (PPARγ) [51] ."
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"Unexpectedly, the antiatherosclerotic effect of USP22 was associated with increased efferocytosis through its ability to bind to peroxisome proliferator-activated receptor γ (PPARγ) and modulate PPARγ stability."
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"We next investigated whether USP22 enhances efferocytosis by regulating PPARγ."
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"Thus, these results suggest that USP22 increases the stability of the PPARγ protein by binding to PPARγ in the nucleus of macrophages."
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"To determine the mechanism of PPARγ reduction, we used the protease inhibitor MG132 to intervene in THP-1-derived macrophages, and the protein reduction in PPARγ caused by Si-USP22 was blocked by MG132 (Fig. 5G)."
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"In addition, we cannot completely exclude the possible role of USP22 in other cell types in atherosclerosis in this study.In conclusion, we showed that USP22 in macrophages promotes efferocytosis and alleviates the progression of atherosclerosis in ApoE mice by regulating PPARγ."
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