IndraLab

Statements

Ergosterol inhibits KCNH2. 4 / 4
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"Another study reported that the fungicidal activity of caffeic acid against T. rubrum was observed at 86.59 μM; this activity was mediated via plasma membrane damage and reduced ergosterol production, where caffeic acid reduced isocitrate lyase activity and downregulated critical genes (ERG1, ERG6, and ERG11) required for ergosterol synthesis [78]."
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"Ergosterol biosynthesis inhibitors that target Erg11, Erg24, Erg2 and Erg1 can also induce the responses."
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"We attempted to replace the native promoter of erg9 ( Merkulov et al., 2000 ) with three different promoters, P ALK1 (−1642 bp from ATG) repressed by glucose and glycerol ( Endoh-Yamagami et al., 2007[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The amount of squalene declined significantly (p = 0.00613) as the accumulation of 2,3-oxidosqualene increased by 4.7-fold (p = 0.00507), which may reflect the absence of ERG9 and ERG1 repression by ergosterol, as well as the enhanced induction of ERG1 due to the lower levels of lanosterol (Table 1) (M’Baya et al. 1989)."
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