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OTUD3 inhibits Interferon. 2 / 2

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"Moreover, overexpression of OTUD3 dose-dependently suppressed Sendai virus (SeV)-induced IFNβ promoter activity in HEK293T cells ( Figure 1 B)."

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"As an acetylation-dependent deubiquitinase, OTUD3 can restrict IFN signaling by directly hydrolyzing the K63-linked poly-ubiquitinated MAVS at K129 residue (Zhang et al., 2020c)."

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Statements

OTUD3 inhibits Interferon. 2 / 2

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