IndraLab

Statements

KCNH2 inhibits (-)-epicatechin-3-O-gallate. 3 / 3
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"When the hERG channel is inhibited, the electrocardiogram (ECG)’s QT interval is extended, which can lead to torsades de pointes and other serious heart rhythm abnormalities."
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"As expected, XREF_FIG shows that hERG block results in QT prolongation and changes in the T wave in the 12 leads of the simulated ECG."
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"Therefore, hERG channel impairment prolongs action potential and, hence, on the ECG, the heart rate-corrected QT interval (QTc, a measure of the ventricular action potential duration)."
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