IndraLab

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USP13 activates Neoplasms. 21 / 22
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"Conversely, overexpression of USP13 promoted xenografted tumor growth, size and weight in vivo (Fig. S2j, k)."
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"We further demonstrated that USP13 obviously promoted OS cells invasion using a 3D tumor spheroid cell-invasion assay (Fig. 2c, d)."
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"Finally, miR‐367 silencing also significantly inhibited 3D cell invasion in tumor spheroids of both USP13‐MED and USP7‐ATRT cells (Fig. 4), suggesting that miR‐367 silencing inhibits two key features of tumor aggressiveness, namely, stem‐like properties and invasive behavior."
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"Importantly, overexpression of Usp13 accelerates tumorigenesis, enhances tumor metastasis, and causes poor outcomes in transgenic mouse models of ovarian cancer , underscoring its importance in promoting tumorigenesis in vivo."
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"USP13 promoted the growth of HCC tumors, since tumors in the USP13 group were larger than those in the NC group."
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"For example, overexpression of USP13 blocks the AKT signaling pathway and suppresses tumor cell proliferation, invasion, and glycolysis by upregulating PTEN, while USP13 levels are downregulated in breast, bladder, and oral squamous tumors, in correlation with PTEN levels (Fig. 3)."
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"In hepatocellular carcinoma, the tumor growth and metastasis are promoted by USP13 through its regulation of TLR4 and subsequent activation of the TLR4/MyD88/NF-κB signaling cascade [23]."
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"The in vivo rescue experiments also indicate that re-expression of USP13 or PTEN can partially restore tumor growth due to PTEN or USP13 knockout, respectively (36)."
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"Nude mouse experiments indicated that depletion of USP13 in GC cells dramatically suppressed tumor growth in vivo."
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"USP13 signaling in tumor metastasis."
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"High expression of USP13 promotes the migration and invasion of tumors such as breast cancer through Twist1 (79)."
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"Notably, USP13 greatly enhanced peritoneal metastasis of ovarian tumors with frequent development of hemorrhagic ascites."
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"Using various in vitro and in vivo functional experiments, USP13 was demonstrated to promote glycolysis and tumor progression in OS."
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"Interestingly, another two studies demonstrated that USP13 could promote tumor progression by deubiquitinating Myc, ACLY and OGDH31, 32, indicating the opposite role of USP13 in tumor progression or inhibition."
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"Combined, the expression of USP13 was elevated in PCa tumors, which may be due to the hyper-methylated level of USP13 gene promoter, and high expression of USP13 indicated poor survival of PCa patients.A."
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"In addition, implanting USP13 knockdown cells to nude mice showed that knockdown of USP13 significantly inhibited HCC tumor growth."
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"Ample findings prove that USP13 may also promote the initiation or progression of various tumors."
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"Collectively, our study results indicate that USP13 promotes glycolysis and tumor progression in OS by stabilizing METTL3, thereby stabilizing ATG5 mRNA and facilitating autophagy in OS."
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"Specific USP13 knockdown in tumor cells can inhibit tumor growth, suggesting that USP13 inhibitors may have therapeutic effects on ccRCC102."
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"Our findings described above revealed the tumor-promoting role of USP13 in HCC."
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"In vivo, USP13 knockdown significantly inhibited tumor growth and lung metastasis."
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