IndraLab

Statements

USP7 activates NLRP3. 11 / 11
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"The DUBs USP7 and USP47 activate the NLRP3 inflammasome, but the specific mechanism is not clear (Palazón-Riquelme et al., 2018)."
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"Inhibition of USP7 and USP47 impairs NLRP3 inflammasome activation in macrophages."
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"USP7 Overexpression Promotes Pyroptosis and NLRP3 Inflammasome Activation in Rat Chondrocytes Through Increasing ROS Production."
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"In addition, inhibition of USP7 and USP47 blocks the NLRP3 inflammasome by preventing apeck-like protein containing a CARD (ASC) oligomerization and speck formation in macrophages [38]."
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"These data suggest that USP7 overexpression promotes NLRP3 inflammasome activation and pyroptosis by increasing ROS production."
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"These results were consistent with the findings in OS cells that mTORC1-stabilized USP7 activated NLRP3 inflammasome pathway (Fig. 7), which was involved in OS progression."
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"USP7 and USP47 also promote NLRP3 activation [55]."
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"These data suggest that USP7 overexpression promotes NLRP3 inflammasome activation and pyroptosis by increasing NOX4."
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"For example, USP7 and USP47 promote the NLRP3 inflammasome by accelerating an apeck-like protein containing a CARD (ASC) oligomerization in macrophages [49]."
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"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
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"It is then possible that this process is regulated by K11 linked ubiquitin chains, yet it is also possible that USP7 and USP47 do not directly target NLRP3 and that an additional regulated protein, upstream of this process, is mediating this effect."
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