IndraLab

Statements

USP7 activates NLRP3. 7 / 7
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"In addition, inhibition of USP7 and USP47 blocks the NLRP3 inflammasome by preventing apeck-like protein containing a CARD (ASC) oligomerization and speck formation in macrophages [38]."
32650621
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"Inhibition of USP7 and USP47 impairs NLRP3 inflammasome activation in macrophages."
30206189
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"These data suggest that USP7 overexpression promotes NLRP3 inflammasome activation and pyroptosis by increasing NOX4."
33584299
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"USP7 Overexpression Promotes Pyroptosis and NLRP3 Inflammasome Activation in Rat Chondrocytes Through Increasing ROS Production."
33584299
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"These data suggest that USP7 overexpression promotes NLRP3 inflammasome activation and pyroptosis by increasing ROS production."
33584299
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"It is then possible that this process is regulated by K11 linked ubiquitin chains, yet it is also possible that USP7 and USP47 do not directly target NLRP3 and that an additional regulated protein, upstream of this process, is mediating this effect."
30206189
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"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
32850399