IndraLab

Statements

JOSD1 decreases the amount of YAP1. 3 / 3
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"We inhibited YAP degradation using the proteasome inhibitor MG132 and found that removal of JOSD1 decreased YAP protein levels in colon cancer cells."
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"The results from these experiments confirmed that JOSD1 inhibited the total ubiquitination level of YAP, particularly the K48-linked ubiquitination level (Fig. 6A–C)."
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"The RNA sequencing data demonstrated that JOSD1 silencing induced dramatic change of Hippo signature (Fig. 1C), while JOSD1 depletion decreased the global YAP target gene expression from GSEA analysis (NES = 1.65; P < 0.001; Fig. 1D)."
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