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Luteolin inhibits RELA. 16 / 19
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"Luteolin inhibited the proliferation of keratinocytes, effectively downregulated the expression of LPS-induced inflammatory mediators, including NF-κB p65 and IL-6, and induced apoptosis of human keratinocytes."
37024790
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"For traumatic brain injury (TBI), luteolin decreased the nuclear accumulation of NF-κB p65 and the production of IL-1β and TNF-α after injury [30]."
35778706
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"These data together suggested that luteolin treatment inhibited the activation of p65, leading to the loss of cyclin D1, an NF-kB target gene."
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"Luteolin activated p-PPARgamma and suppressed LC3B and p-NF-kappaB p65 proteins in damaged hippocampus in MCAO/R treated rats."
35778706
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"As shown in Fig. 4 , we found that Apigenin and Luteolin significantly inhibited NF-κB activation induced by overexpression of NF-κB p65 and GAL4DBD-p65/RelA, indicating that these flavonoids inhibit [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, Luteolin treatment down-regulates NF-κB p65 in the nucleus and p–NF–κB-p65 to varying degrees."
34478730
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"Further findings demonstrated that luteolin inhibited the activation of ERK, JNK, p38, and NF-kappaB p65 in the IL-33-stimulated HMC-1.2 cells."
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"Furthermore, luteolin decreased nuclear accumulation of p65 induced by TBI, indicating attenuation of inflammation."
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"As shown in Fig. 6 A, LPS induced intra-nuclear translocation of p65, which was inhibited by the combination of paeoniflorin and luteolin."
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"Moreover, luteolin attenuated IS-induced nuclear accumulation of p65 and c-jun."
39105397
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"Immunocytochemistry results revealed luteolin can inhibit TNF-alpha-stimulated p65 from nuclear translocation as a transcription factor and thus promoting cell apoptosis."
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"Our report demonstrated that luteolin inhibited the interaction of p65 with CBP and that this event was directly related to the inhibition of NF-kappaB transcriptional activity."
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"Kao et al. found that luteolin decreased the LPS and IFN-gamma-induced nuclear accumulation of p65 and Rel B but not p50, suggesting partial inhibition of NF-kappaB activation in BV-2 microglial cells[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29801717
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"also observed that luteolin treated cells showed decreased IkappaBalpha degradation induced by TNF-alpha and significantly decreased NF-kappaB p65 nuclear translocation (Jia et al., 2015)."
29801717
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"Since the destruction of the BSCB is usually the inevitable result of SCI, Lu et al. [72] identified that MSCs derived exosome-conducted treatment could inhibit the migration of pericytes and improve the integrity of BSCB through nuclear factor κB (NF-κB) p65 signaling in pericytes."
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"ELISAs were performed to measure IL-6 and proET-1 to examine the downstream effects of luteolin inhibition of TNF-α-induced p65 activation in placental explants."
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