IndraLab

Statements

OTUB1 inhibits RNF168. 3 / 4
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"While OTUB2 plays a negative role in removing RNF8-mediated K63-linked ubiquitylation on an early pathway component [11], OTUB1 inhibits RNF168-mediated K63-linked ubiquitylation on DNA damage sites in the late phase of DDR by binding and prohibiting Ube2N-Ube2V catalysis [12,13]."
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"OTUB1 inhibits the RNF168 E2 enzyme UBE2N (and probably also other E2s) independently of its de-ubiquitylating activity [XREF_BIBR, XREF_BIBR]."
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"OTUB1 inhibits both RNF168 stimulated formation of free polyubiquitin chains as well as the chains produced by the basal activity of Ubc13 itself."
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