IndraLab

Statements


OTUB1 inhibits RNF168. 2 / 3
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"OTUB1 inhibits both RNF168 stimulated formation of free polyubiquitin chains as well as the chains produced by the basal activity of Ubc13 itself."

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"OTUB1 inhibits the RNF168 E2 enzyme UBE2N (and probably also other E2s) independently of its de-ubiquitylating activity [XREF_BIBR, XREF_BIBR]."