IndraLab

Statements

USP3 inhibits DNA Breaks, Double-Stranded. 2 / 2
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"USP3 [57], USP16 [58], USP29 [59], USP44 [59], USP49 [60], USP51 [61], A20 [62], BRCC36 [63], and OTUB1 [64] have been suggested to inhibit DSB-induced histone H2A ubiquitination."
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"Knockdown of USP3 alone activates the DSB response, as determined by a number of factors including a delay in S-phase progression, an increased number of DNA breaks and structural abnormalities, ATM/ATR activation, and γH2AX staining [109,132,134]."
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