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Toxins LmKTx2 inhibits KCNQ1. 1 / 1

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"After screening five newly identified acidic peptides and three known peptides (BmP01, BmP02, and PbTx1), we found that each of the acidic toxins had different effects on KCNQ1 : toxin ImKTx104 was the first selective inhibitor of KCNQ1 with a K d of 11.69 microM; toxin HeTx204 blocked Kv1.3 and KCNQ1 at micromolar concentration; toxins LmKTx2, HeTx203, BmP02, and PbTx1 could weakly inhibit KCNQ1 at 10 microM level; and toxins StKTx23 and BmP01 had a minor effect on KCNQ1 at 10 microM concentration."

22511981

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Toxins LmKTx2 inhibits KCNQ1. 1 / 1

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