IndraLab

Statements

USP14 activates 2,5-diphenylfuran. 4 / 4
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"Over-expression of a catalytically inactive form of USP14 rescues the PPF deficit and restores synaptic vesicle number, indicating that USP14 regulates presynaptic structure and function independently of its role in deubiquitination."
24218545
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"On the other hand, restoration of proteasomal activity and hence expression of USP14 and presynaptic proteins rescued PPF in SPL fl/fl/Nes mice."
27883090
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"To determine whether the BALBnmf375 mice were also resistant to the PPF deficit caused by USP14 deficiency in the C57ax J mice, we analyzed PPF in the CA1 region of the nmf375 hippocampus."
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"XREF_BIBR a reduction in the deubiquitinating enzyme USP14 impairs PPF without changing the initial release probability."
27883090