IndraLab

Statements

Eplerenone inhibits NLRP3. 2 / 2
| 2
reach
"In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1, and IL-18 expressions in dose- and time dependent manners, indicating an activation of NLRP3 inflammasome, which was significantly blocked by the mineralocorticoid receptor antagonist eplerenone or the antioxidant N -acetylcysteine."
28052869
reach
"Furthermore, eplerenone attenuates M1-polarization of macrophages and inhibits the activation of NLR family pyrin domain containing 3 (NLPR3)-inflammasome, a key mediator of the inflammatory response [64]."
36432422