IndraLab

Statements

TP53 bound to X activates TP53. 4 / 4
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"The binding of HBx to p53 modulated (but did not inhibit) the transcriptional activation function of p53."
16055925
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"In HCC cells and transgenic mice expressing HBx, binding of p53 to HBx causes cytoplasmic retention of the p53 tumor suppressor gene product, thus completely blocking the translocation of p53 to the n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22510407
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"The tumor suppressor p53 can also be bound by HBx in the cytoplasm and prevent p53 nuclear localization."
33132633
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"HBx causes transcriptional repression of the p53 gene and interacts with p53 to inactivate several important p53 dependent activities, including apoptosis, cell-cycle regulation, DNA repair and tumor suppression."
20228847