IndraLab

Statements

Ibrutinib inhibits CASP1. 9 / 10
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"Ibrutinib also suppresses NLRP3 inflammasome activation and caspase-1 activity, thus blocking maturation of IL-1β in infiltrating neutrophils in a mouse model of ischemic brain injury (Ito et al., 2015)."
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"Being consistent with reduced mature IL-1beta production (XREF_FIG), immunofluorescence staining revealed that ibrutinib treatment strongly suppressed caspase-1 activation in the infarcted area of the brain (XREF_FIG)."
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"Ibrutinib suppresses IL-1β maturation by blunting caspase-1 stimulation in macrophages and neutrophils, which infiltrate in the ischemic brain infarct."
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"Indeed, pro-IL-1beta and caspase-1 processing in primary MoMacs was strongly reduced by both ibrutinib and CGI1746 (Fig 2, F)."
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"Platelet caspase-1 and Bruton tyrosine kinase activation in patients with COVID-19 is associated with disease severity and reversed in vitro by ibrutinib."
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"Four-week IP injections of ibrutinib significantly diminished platelet caspase-1 activity in SCD mice, which did not occur in control mice (Fig. 1B)."
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"Caspase 1 activity rose sharply and significantly in stressed mice which were vehicle treated, however, Ibrutinib treatment significantly attenuated the Caspase 1 activity in hippocampus of both male and female stressed mice (p < 0.001)."
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"Nevertheless, our results show that the ibrutinib administration in stressed mice attenuates the IL1β in plasma and Caspase 1 activity in PBMCs, indicating that ibrutinib regulates peripheral immune responses in addition to its central effect.In summary, we present novel and robust proof-of-concept findings, and provide the first evidence of BTK as a key driver of anxiogenesis and proinflammatory NLRP3–IL1β pathway in a rodent model of stress."
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"Caspase 1 activity rose sharply and significantly in stressed mice which were vehicle treated, however, ibrutinib treatment significantly attenuated the Caspase 1 activity in hippocampus of both male and female stressed mice (p < 0.001)."
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