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VIRF-3 activates USP7. 1 / 1
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"Here, we identify ubiquitin specific protease 7 (USP7) deubiquitinase targeting by vIRF-3 (in addition to previously reported USP7 binding by vIRF-1 and vIRF-4), the importance of vIRF-1 and vIRF-3 interactions with USP7 for latent PEL cell growth and viability, and the positive and negative contributions, respectively, of USP7 targeting by vIRF-1 and vIRF-3 to HHV-8 productive replication."