IndraLab

Statements

Lipopolysaccharide inhibits IRF7. 4 / 4
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"Consistently, immunosuppressive upstream regulator IL-10RA was activated ( Figure S3C ) while canonical proinflammatory TNFSF10, IFNB1 and IRF7 were inhibited by C498+LPS when compared to the LPS group ( Figure 3I )."
37122731
reach
"The data showed that LPS stimulation significantly activated the IFN-I signalling pathway, and knockdown of MEF2D markedly inhibited the elevation of IRF7, IFNA1, MX2, IFIT1, IFI27, ISG15, RSAD2, ZBP1 and DDX58 (XREF_FIG)."
34234510
reach
"The critical importance of IRF mediated signaling to the neuroprotective process is shown clearly by the fact that mice lacking IRF3 or IRF7 fail to be protected or exhibit much reduced protection when treated with CpG, LPS or brief ischemia."
21653850
eidos
"Thus , the present finding that IRF7 was upregulated by LPS and downregulated in response to AST treatment may suggest that of AST protects against ALI ."
32969837