IndraLab

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KCNH2 inhibits apoptotic process. 17 / 18
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"Because KCNE2 partially suppresses hERG currents by reducing unitary conductance and speeding deactivation XREF_BIBR, it is an intriguing possibility that the observed anti-proliferative effects of KCNE2 overexpression in vitro XREF_BIBR are due to hERG current suppression promoting apoptosis, and conversely that KCNE2 down-regulation or genetic disruption may favor gastric cellular proliferation by increasing hERG current density."
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"Given that GB cells express hERG channels and that hERG suppression by doxazosin induces apoptosis, we hypothesized that pharmacological targeting of hERG channels would induce apoptosis of GB cells."
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"Silencing HERG inhibited the apoptosis induced by cisplatin both in vitro and in vivo, by attenuating the cisplatin effects on Bcl-2, Bax and active caspase-3."
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"Inhibition of hERG by doxazosin, an antihypertensive drug, has been shown to promote apoptosis by a not fully clarified mechanism [49] ."
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"To delineate the mechanism of action behind hERG1 promotion of osteosarcoma cell proliferation, we examined whether inhibition of hERG1 triggers apoptosis."
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"Kcnh2 depletion induces embryonic apoptosis rather than inhibiting proliferation."
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"Moreover, knockdown of hERG inhibits cell growth and induces apoptosis in ATC cells in vitro."
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"These results suggested that KCNH2 is necessary to prevent apoptosis during embryo development."
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"In addition, hERG channel blockers can lead to apoptosis; however, this event appears to be independent of their ability to arrest the cell cycle."
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"Of interest, the hERG1 Kz channelinhibitor enhanced SDF-1-induced apoptosis."
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"In this study, it was found that hERG1 silencing induced apoptosis in osteosarcoma cells."
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"Amiodarone repressed H9c2 cell viability and KCNH2 level and triggered apoptosis, ROS production and mitochondrial depolarization, while Sigmar1 upregulation reversed its effects."
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"Furthermore, gene knockdown of hERG elicited growth suppression as well as activated apoptosis by means of abolishing vascular endothelial growth factor secretion and triggering caspase-3 cascade in anaplastic thyroid carcinoma cells."
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"For instance, inhibitors of Kv10.1 and hERG channels have been shown to reduce proliferation and induce apoptosis in BC cells (Peretti et al., 2019)."
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"HERG channel blockers have been shown to induce apoptosis in different cell types."
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"Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-kappaB Pathway."
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"The present study demonstrated that KCNH2 depletion in rat embryos led to apoptosis but not proliferation, especially in the embryonic heart."
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