IndraLab

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Ubiquitin inhibits USP25. 2 / 2

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"VRK2 phosphorylates ubiquitin-specific protease 25 (USP25) and inhibits the deubiquitinating activity of USP25, which further increases polyglutamine aggregation [6,7]."

38186576

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"Recovery of ubiquitin variants inhibiting USP21 with low nanomolar IC 50 concentrations validates our strategy and illustrates that a small 6000 computationally designed library can recover hundreds of variants whose sequences are diverse, yet tightly bind a targeted protein."

27453948

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IndraLab

Statements

Ubiquitin inhibits USP25. 2 / 2

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