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COPS5 activates cell differentiation. 10 / 11
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"Interestingly, JAB1 activated CPNE1 related neuronal differentiation."
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"We found that increased expression of JAB1 promoted odontogenic differentiation of DPSCs via Wnt and beta-catenin signaling."
26989054
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"Odontoblastic differentiation of DPSCs can be promoted by increased expression of Jun activation domain-binding protein 1 (JAB1), a multipotent protein stabilizing proteins and controlling cell proliferation, via Wnt/β-catenin signaling, as the expression of GSK3β and β-catenin was dramatically increased (Lian et al., 2016)."
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"Upregulation of COPS5 in both FGF8 treatments is suggestive of enhanced odontogenic differentiation in line with increased COPS5 expression being able to promote the odontogenic differentiation of DPS[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The quantitative summary indicated that the BMP signaling (ratio: p-Smad/total Smad) was approximately 2.2-fold higher at 12 h compared with that at the onset of NSC differentiation, and it decreased [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of JAB1 enhanced CPNE1-dependent differentiation of HiB5 indicating a synergistic effect of JAB1 and CPNE1 during neuronal differentiation even though the underlying mechanism deserves further clarification (Yoo et al. 2018)."
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"JAB1 accelerates odontogenic differentiation of dental pulp stem cells."
26989054
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"Interestingly, JAB1 activated CPNE1 related neuronal differentiation."
29448099
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"Moreover, JAB1 also interacted with Brn-2 and possibly activated Brn-2 downstream signaling pathway in neuronal differentiation (Huang et al. 2005)."
37365502
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"Moreover, the knockdown of Jab1 attenuated 5-HT 6 R agonist induced-Runx2 suppression as well as osteoblast differentiation as evidenced by ALP staining (XREF_FIG) and activity (F) and differentiation markers, ALP, OCN, and bone sialoprotein (BSP) (XREF_FIG)."
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