IndraLab

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Hydroxychloroquine activates doxycycline. 5 / 5
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"It is worth noting that the activity of carbenicillin, vancomycin, ofloxacin, clarithromycin, tigecycline, nisin, and hydroxychloroquine when combined with doxycycline only marginally enhanced doxycycline activity and their anti-persister activities were not as effective as when they were combined with daptomycin (XREF_TABLE)."
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"In fact, HCQ was shown to increase the phagolysosomal compartment 's pH by improving the bactericidal activity of doxycycline [125,126]."
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"On the other hand, HCQ was then added at a concentration of 6 μg/mL to each increased levels of AZI i.e. 0.2, 2, 10, 100, and 400 μg/mL to produce HCQ 6 μg/mL + AZI.Fig 8: The cytotoxicities of Hydroxychloroquine (HCQ) and Doxycycline (DOXY) as a single drug (left) and dual drug combination in constant and non-constant ratios (right) analysed by using CompuSyn Software (n = 3)."
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"By analogy with C. burnetii, HCQ restores the intracellular activity of doxycycline in vitro [8] and a clinical trial using this regimen is under evaluation."
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"Hydroxychloroquine potentiates the bactericidal activity of doxycycline by alkalinizing the vacuolar pH [XREF_BIBR]."
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