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USP8 inhibits SQSTM1. 2 / 2

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"In addition to ubiquitin ligases, the deubiquitinating enzyme USP8 inhibits this decoration of p62 at the K420 residue and acts as a negative regulator of autophagy ( Figure 3D)."

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"The knockdown of USP8 promoted autophagic degradation of SQSTM1/p62 (p62), decreasing the p62 adaptor protein in HEK293T cells."

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IndraLab

Statements

USP8 inhibits SQSTM1. 2 / 2

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