IndraLab

Statements

OTUD7B increases the amount of PIK3C3. 3 / 3
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"In addition, OTUD7B knockdown significantly decreased levels of the autophagosome formation markers VPS34, ATG14L, and ATG7 and significantly increased p62."
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"As shown in Fig. 3A, our results showed that OTUD7B knockdown significantly decreased the levels of VPS34, ATG14L, p-Becline1, ATG7, and LC3B-II/I, while levels of P62 were significantly increased compared with the negative control cell."
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"Besides, we noticed that, in PC9 cells, Cezanne knockdown decreased PIK3C3 expression with or without the effect of CHX at protein level (Fig. 3D) but not mRNA levels (Supplementary Fig. 1C), and the addition of MG132 could recuse it (Fig. 3D)."
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