IndraLab

Statements


6 2 | 2 2

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sparser
"Otherwise, USP8 binds Gads via its SH3BM domain, and ectopic re-expression of SH3BM-laking mutant of USP8 do not restore T cell development."

sparser
"Mechanistically, USP8 interacts with Gads and 14-3-3β, forming a complex with the T cell receptor (TCR)−CD28 cluster upon stimulation."

reach
"First, the authors found that USP8 could bind to the TCR adaptor Gads and the regulatory molecule 14-3-3, whereas USP8 was regulated in a caspase-dependent manner."

reach
"The novel interactions between Gads and UBPY, BLNK, and Gab2 were confirmed by in vitro binding experiments using GST-Gads fusion proteins."

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