IndraLab

Statements

AGT inhibits KCNK2. 5 / 5
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"Inhibition of TREK1 by AngII was found to be due to a rise in [Ca 2+] i rather than PIP2 depletion [XREF_BIBR]."
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"Inhibition of TREK1 by AngII was found to be due to a rise in [Ca 2+ ] i rather than PIP2 depletion [ xref ]."
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"This leak-type K + channel, later identified as TREK-1 of the two-pore K + (K2P) channel family, was potently inhibited by ACTH and AngII, leading directly to membrane depolarization."
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"Bovine adrenocortical cells express bTREK-1 K (+) (bovine KCNK2) channels that are inhibited by ANG II through a Gq coupled receptor by separate Ca (2+) and ATP hydrolysis dependent signaling pathways."
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"Both AngII and vasopressin strongly inhibited (~70–80%) TREK1 and depolarized the cells by ~30 mV [ xref ]."
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