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USP4 deubiquitinates TRIM21. 2 / 2
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"In the cytosol, USP4 deubiquitinates the member of many vital cell signaling pathways, e.g., NF-κB [77], TGF-β [54], Wnt/β-catenin [78], and p53 [79] as well as adenosine A2A receptor [80] and the E3 ligase TRIM21 [81]."

"Oncogenic protein UnpEL/<span class="match term0">Usp4</span> deubiquitinates <span class="match term1">Ro52</span> by its isopeptidase activity"