IndraLab

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USP8 inhibits autophagy. 7 / 7
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"*USP8 negatively regulates the TRAF6-mediated signals for NF-kappaB and autophagy."
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"We show here that UBPY silencing also activates autophagy in absence of CCCP treatment, which strongly suggests that UBPY is not connected exclusively to mitophagy."
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"Autophagy promotes tumor progression at advanced stages of tumor development, and USP8 negatively regulates the autophagy by deubiquitinating p62 (SQSTM1) at K420 [36,[50], [51], [52]], supposing that USP8 may be negatively implicated in the tumor progression via the regulation of autophagy."
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"More recently, it was reported that USP8 negatively regulates autophagy by deubiquitinating the autophagy factors TRAF6, BECN1 and p62 [16], supporting the hypothesis that USP8 reduction can be used to promote autophagy."
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"USP8 inhibition increased autophagy flux, as shown by the staining of LC3 puncta and clearance of p62."
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"USP8 inhibitor , DUB-IN-1 , treatment could inhibit esophageal squamous cell carcinoma cell growth and induce G2 / M cell cycle arrest , apoptosis , and autophagy by DNA damage-induced p53 activation ."
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"USP8 inhibition was also shown to enhance autophagy, a host process involved in clearing intracellular bacteria."
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