IndraLab

Statements

UbV.2.6 inhibits USP2. 3 / 3
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"To better understand the basis for the potent inhibition of USP2 by UbV.2.6, we introduced each of the four substitutions from UbV.2.6 individually into the sequence of Ub.wt and assessed effects on U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The substitutions at positions 6 and 11 had the greatest effects, and indeed, a UbV bearing substitutions at both positions was only 6-fold less potent than Ub.V.2.6.To better understand the basis for[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, the mutational and structural analyses revealed that a triad of substituted residues in UbV.2.6 forms the center of the interface with USP2, and the side chains of Cys 6 and Arg 11 sub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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