IndraLab

Statements



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"Also, Otub1 promotes UV-irradiation-induced apoptosis, which can be inhibited by MDMX depletion."

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"Together, these results suggest that Otub1 also induces mitochondrial mediated apoptosis by stabilizing MDMX and relocalizing it to mitochondria to induce mitochondria mediated apoptosis."

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"Taken together, our findings show that OTUB1 induces apoptosis of melanoma cells in vitro, likely by upregulating TRAIL, and suggest that approaches targeting OTUB1 can be developed to provide novel therapeutic strategies for treating melanoma."

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"As described in our previous work, Otub1 stabilizes and activates p53 and can induce apoptosis [XREF_BIBR]."

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"Otub1 promotes UV induced apoptosis that involves MDMX stabilization."

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"In this context, OTUB1 might be a potential target for new therapies of OSCC.As a key and star deubiquitinating enzyme, OTUB1 mediates ferroptosis, immunity, apoptosis, and autophagy in tumor and non-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Consequently, overexpression of Otub1 induces p53 dependent apoptosis and inhibition of cell proliferation whereas knockdown of Otub1 attenuates p53 activation following DNA damage [XREF_BIBR]."

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"Interestingly, our results also show that OTUB1 downregulation significantly induced apoptosis in melanoma cells."

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"Consistently, silence of Otub1 promotes the degradation of c-Maf and MM cell apoptosis."

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"The result showed that AVT drastically reduced the protein level of pro-caspase-3 in both RPMI-8226 and LP1 cells, but it was abolished partly by lentiviral Otub1, suggesting Otub1 expression rescued the apoptosis induced by AVT."

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"It has also been reported that OTUB1 promotes apoptosis by preventing the degradation of p53 via the MDM2/MDMX-mediated ubiquitination proteasome system [30,31]."

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"Overexpression of OTUB1 induces p53 dependent apoptosis whereas its knockdown attenuates p53 activation."

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"In addition, OTUB1 also promotes UV induced apoptosis."

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"Furthermore, Otub1 promotes UV-irradiation-induced p53S46P and apoptosis, which can be significantly inhibited by MDMX depletion."

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"Together, these results suggest that Otub1 stabilizes MDMX and promotes p53S46P and mitochondria mediated apoptosis, providing an alternative mechanism of Otub1 's role in apoptosis."

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"Despite a recent report that OTUB1 stabilizes MDMX and induces apoptosis 46, OTUB1 stabilizes proteins linked to cancer progression such as RAS and FOXM1 via deubiquitination and promotes tumor growth and invasion 34,47."