IndraLab

Statements

OTUB1 activates apoptotic process. 11 / 15
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"As described in our previous work, Otub1 stabilizes and activates p53 and can induce apoptosis [XREF_BIBR]."
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"In addition, OTUB1 also promotes UV induced apoptosis."
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"Otub1 promotes UV induced apoptosis that involves MDMX stabilization."
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"Together, these results suggest that Otub1 stabilizes MDMX and promotes p53S46P and mitochondria mediated apoptosis, providing an alternative mechanism of Otub1 's role in apoptosis."
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"Together, these results suggest that Otub1 also induces mitochondrial mediated apoptosis by stabilizing MDMX and relocalizing it to mitochondria to induce mitochondria mediated apoptosis."
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"Consequently, overexpression of Otub1 induces p53 dependent apoptosis and inhibition of cell proliferation whereas knockdown of Otub1 attenuates p53 activation following DNA damage [XREF_BIBR]."
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"Also, Otub1 promotes UV-irradiation-induced apoptosis, which can be inhibited by MDMX depletion."
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"Taken together, our findings show that OTUB1 induces apoptosis of melanoma cells in vitro, likely by upregulating TRAIL, and suggest that approaches targeting OTUB1 can be developed to provide novel therapeutic strategies for treating melanoma."
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"The result showed that AVT drastically reduced the protein level of pro-caspase-3 in both RPMI-8226 and LP1 cells, but it was abolished partly by lentiviral Otub1, suggesting Otub1 expression rescued the apoptosis induced by AVT."
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"Furthermore, Otub1 promotes UV-irradiation-induced p53S46P and apoptosis, which can be significantly inhibited by MDMX depletion."
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"Overexpression of OTUB1 induces p53 dependent apoptosis whereas its knockdown attenuates p53 activation."
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