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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

IKK_complex binds TRAF2, TRAF6, and CYLD. 1 / 1

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"The initial clue to the signaling function of CYLD came from an RNAi-based functional screening study, which identified CYLD as a DUB that negatively regulates NF- κ B activation. xref At the same time, yeast two-hybrid screening studies identified CYLD as a protein that binds to NF- κ B essential modulator (NEMO), a regulatory subunit of I κ B kinase (IKK). xref , xref CoIP assays also revealed the association of CYLD with two IKK regulatory proteins, TRAF2 and TRAF6, and subsequent studies identified additional molecular targets of CYLD ( xref )."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...