IndraLab

Statements

USP22 activates Parkinson Disease. 3 / 3
| 3
reach
"Conversely, ectopic expression of USP22 caused an enhancement in PD‐L1 protein expression, and further attenuating the upregulatory effect of Taz on PD‐L1 expression (Figure 3D,E)."
38520088
reach
"Conversely, ectopic USP22 expression enhanced the stability of PD‐L1 and prolonged its half‐life, as well as enhanced resistance to T‐cell cytotoxic effects and resulted in an increase in cell viability (Figure 4D–F; Figure S4B, Supporting Information)."
38520088
reach
"For example, in hepatocellular carcinoma USP22 upregulates PD‐L1 and induces the exhaustion of tumor infiltrating CD8+ T cells, 32 while in the colorectal carcinoma it targets BMI‐1, c‐MYC, CYCLIN D2, p16INK4a, and p14ARF, so exerting a crucial role in tumor proliferation."
39255961