IndraLab

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OTUD5 bound to GPX4 activates GPX4. 1 / 1

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"As OTUD5 belongs to the DUBs family and plays a critical role in controlling the Ub‐dependent degradation of various proteins, 4‐HNE may reduce the interaction between OTUD5 and GPX4 to promote GPX4 ubiquitination and subsequent degradation.To test whether OTUD5 affects the protein stability of GPX4, we co‐transfected GPX4 with Flag‐OTUD5 or its enzyme‐inactive mutant C224S into HEK293T cells."

37552043

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IndraLab

Statements

OTUD5 bound to GPX4 activates GPX4. 1 / 1

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