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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 inhibits JNK. 2 / 2

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"MIF can also interact with intracellular binding proteins, such as JUN-activation domain-binding protein 1 (JAB1), through which it can block the activity of JNK pathway and its target transcription factor AP-1 (128)."

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"MIF signals through at least three cell surface receptors, including the CD74/44 complex, CXCR2 and CXCR4 16-18 but also signals by intracellular interaction with the JAB-1 thus inhibiting JNK activation and p27 Kip1 -dependent cell-cycle regulation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...