IndraLab

Statements

Spadin binds KCNK2. 4 / 4
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"We demonstrated that TREK‐1 binds to the PDZ domain of NHERF‐1 and that this interaction regulates spadin‐sensitive astrocytic passive conductance (Figure 8)."
39543986
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"More recent work has shown that spadin, a peptide derived from the maturation of the neurotensin receptor 3, specifically binds to TREK-1, blocking channel activity in vitro and increases the firing rate of 5-HT neurons of the raphe in vivo."
33210730
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"XREF_FIG shows that spadin bound specifically to TREK-1 with an affinity of about 10 nM."
20405001
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"Taken together, these results indicate that TREK-1 and NTSR3 and Sortilin are not only associated within the plasma membrane but that spadin interacts directly with TREK-1 to functionally inhibit its activity."
20405001