IndraLab

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OTUB1 deubiquitinates AKT. 5 / 5
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"OTUB1 mediates the activation and metabolism of T cells through deubiquitinating AKT."
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"OTUB1 deubiquitinates AKT, inhibiting its phosphorylation and activation; T cell-specific Otub1 deficiency (Otub1 CD4 mice) induced more CD8 T cell proliferation and greater IFN-γ and TNF-α production in response to IL-15 [81]."
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"Conversely, Otub1 overexpression inhibited AKT ubiquitination, which was efficient for K63-linked, but not K48-linked, polyubiquitin chains (Fig. 5f)."
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"These results suggest that Otub1 deubiquitinates AKT to interfere with the PIP3-binding and membrane translocation of AKT, thereby inhibiting its phosphorylation and activation."
31182807
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"Otub1 is recruited to the membrane upon IL-15 signalling, and deubiquitinates the PH binding domain of AKT, thus reducing its ability to bind to PIP and get activated."
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