IndraLab

Statements

USP37 activates Deubiquitinase. 3 / 3
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eidos
"Mechanistically , they found that USP37 counteracts APC / C-mediated ubiquitination of cyclin A , and that USP37 itself is phosphorylated by cyclin A-Cdk2 to increase its DUB activity and allow S-phase entry ."
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reach
"Activation by phosphorylation also takes place during the cell cycle, where USP37 is modified by CDK-2 to directly stimulate DUB activity [74] ."
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"Subsequent phosphorylation of USP37 by either CDK2 and cyclin E or CDK2 and cyclin A triggers its full DUB activity."
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