IndraLab

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CRISPR-Cas9 inhibits OTUD3. 3 / 3
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"The efficiency of OTUD3 knockdown mediated by CRISPR-Cas9 (OTUD3 KD#1 and OTUD3 KD#2) was confirmed by western blotting ( Figure S2 E)."
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"In contrast, knockdown of OTUD3 by CRISPR-Cas9 (OTUD3-KD #2) in HEK293T cells enhanced K63-linked polyubiquitination in the absence of viral infection ( Figures 2 C and 2D) and in the presence of SeV [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, knockdown of OTUD3 by CRISPR-Cas9 (OTUD3-KD#1 and OTUD3-KD#2) in HEK293T cells enhanced its activity ( Figure 1 C), as well as the SeV-induced IFNβ promoter activity ( Figure 1 D)."
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