IndraLab

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QKI increases the amount of CACNA1C. 3 / 3
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"We also found that overexpression of QKI elevated CACNA1C mRNA and protein expression, while QKI knockdown mediated by the CRISPR and Cas9 system inhibited CACNA1C expression in both HL-1 and primary cultured cardiomyocytes."
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"In contrast, QKI knockout inhibited CACNA1C expression."
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"Furthermore, we showed that QKI not only upregulated CACNA1C expression, but also enhanced the level of I Ca-L, which plays important roles in the pathogenesis of AF."
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