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USP18 leads to the dephosphorylation of STAT. 2 / 2

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"Hence, through stabilizing the interaction between STAT2 and IFNAR2, USP18 may also negatively regulate the STAT phosphorylation process by decreasing the STAT phosphorylation turnover rate and the activation of the ISGF3 complex."

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"Patient-derived fibroblasts showed enhanced IFN-induced inflammation and enhanced and prolonged STAT phosphorylation which could be reversed by transduction of cells with wild-type USP18."

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IndraLab

Statements

USP18 leads to the dephosphorylation of STAT. 2 / 2

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