IndraLab

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TBX5 increases the amount of SCN5A. 4 / 4
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"p.D111Y Tbx5 increased SCN5A expression but failed to repress CAMK2D and SPTBN4."
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"TBX5, which plays a fundamental role during cardiac development, stimulates SCN5A expression in the adult cardiac conduction system by binding gene enhancer elements (Arnolds et al., 2012; Van Den Boo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Tbx5 increased transcription of SCN5A encoding cardiac Nav1.5 channels, while repressing CAMK2D and SPTBN4 genes encoding Ca-calmodulin kinase IIdelta (CaMKIIdelta) and betaIV-spectrin, respectively."
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"In particular, the T-box transcription factor TBX3 suppresses, whereas the related factor TBX5 enhances transcription of SCN5A and SCN10A in mouse heart by interacting with conserved binding sites located within these two neighboring genes."
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