IndraLab

Statements

Kcnq1ot1 increases the amount of KCNQ1. 3 / 3
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"Kcnq1ot1 mediates chromatin conformation and Kcnq1 level in the developing heart [ 15 ]."
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"Knockdown of Kcnq1ot1 was observed to reduce mRNA and protein levels of KCNQ1, thereby prolonging APD and QTc interval in neonatal mouse cardiomyocytes and mice."
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"This result coincided with the up-regulated transcription of KCNQ1 in the spinal cord of human NTDs (XREF_FIG), because hypermethylated KvDMR1 is known to inhibit the expression of the lncRNA Kcnq1ot1 gene, and loss function of Kcnq1ot1 consequently promotes KCNQ1 transcription (XREF_FIG) XREF_BIBR."
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