IndraLab

Statements

USP22 leads to the deubiquitination of CTNNB1. 3 / 3
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"In contrast, the overexpression of USP22 promoted nuclear beta-catenin deubiquitination and enhanced the neuroprotective effects offered by HPC."
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"Further, the upregulation of nuclear USP22 induced by HPC promotes the methylation of nuclear β-catenin after USP22-mediated deubiquitination, which enhances the stability of nuclear β-catenin in CA1 and protects ischemic neuron against cerebral ischemia."
39934243
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"Our data revealed that nuclear β-catenin deubiquitination induced by USP22 overexpression significantly increased the methylation of nuclear β-catenin after tGCI."
39934243