IndraLab

Statements

USP2 deubiquitinates SMAD7. 3 / 3
| 3
reach
"It has established that USP2 functions as a tumor suppressor in numerous malignancies through multiple mechanisms; for instance, USP2 deubiquitinates SMAD7 and suppresses TGF-β signaling pathway to inhibit glioblastoma progression [19]."
40011884
reach
"USP2 leads to de-ubiquitination and stabilization of SMAD7, and USP2 loss results in an increased SMAD7 ubiquitination and increased phospho-SMAD2 [61]."
38256140
reach
"Specifically, USP2 interacted with SMAD7 and prevented SMAD7 ubiquitination."
35332268